100+ Peer-Reviewed Publications

Based on early experiments conducted by scientists Dieter Manstein, MD, PhD and R. Rox Anderson, MD, cryolipolysis, the concept behind CoolSculpting®, was invented.

Read about the CoolSculpting cryolipolysis procedure, the non-invasive fat reduction treatment with the most peer-reviewed publications.


Safety and Efficacy of Submental cryolipolysis

Bernstein, E.F., Bloom, J.D. Safety and Efficacy of Submental cryolipolysis. JAMA Facial Plastic Surg.

Long-term follow-up shows lasting results

Bernstein EF. Longitudinal Evaluation of cryolipolysis Efficacy. J Cosmet Dermatol.

No Impact On Serum Lipid Levels & Liver Function

Klein, K. B., Bachelor, E. P., Becker, E. V. and Bowes, L. E. Multiple same day cryolipolysis treatments for the reduction of subcutaneous fat are safe. Lasers in Surg.

Visible improvement & high patient satisfaction

Dierickx CC, Mazer JM, Sand M, et al. Safety, Tolerance, and Patient Satisfaction With Noninvasive cryolipolysis. Dermatol Surg.

Significant clinical practice business growth

Stevens WG, Pietrzak LK, Spring MA.Broad Overview of a Clinical and Commercial Experience With CoolSculpting. Aesthetic Surg J.

Efficacy on “Love Handle” fat layer reduction

Dover J, Burns J, Coleman S, et al. A Prospective Clinical Study of Noninvasive cryolipolysis for Subcutaneous Fat Layer Reduction

No impact on lipid & liver function

Klein KB, Zelickson B, Ropelle JG, et al. Noninvasive cryolipolysis for Subcutaneous Fat Reduction Does Not Affect Serum Lipid Levels or Liver Function Tests. Lasers Surg Med.

No evidence of long-term nerve injury

Coleman SR, Sachdeva K, Egbert BM. Clinical Efficacy of Noninvasive cryolipolysis and Its Effects on Peripheral Nerves. Aesthetic Plast Surg.

Efficacy & safety demonstrated in studies

Avram MM, Harry RS. cryolipolysis for Subcutaneous Fat Layer Reduction. Lasers Surg Med.

Cryolipolysis reduces excess adipose tissue

Nelson AA, Wasserman D, Avram MM. cryolipolysis for the Reduction of Excess Adipose Tissue. Semin Cutan Med Surg.

Decreases fat and changes body contour

Zelickson B, Egbert BM, Preciado J, et al. cryolipolysis for Noninvasive Fat Cell Destruction: Initial Results From a Pig Model. Dermatol Surg.

Proof of concept for cryolipolysis

Manstein D, Laubach H, Watanabe K, et al. Selective Cryolysis: A Novel Method of Noninvasive Fat Removal. Lasers Surg Med.

CoolSculpting® Indications
CoolSculpting® procedure is FDA-cleared for the treatment of visible fat bulges in the thigh, abdomen and flank, along with bra fat, back fat, underneath the buttocks (also known as banana roll), and upper arm in patients with a Body Mass Index (BMI) of ≤ 30 and in submental and submandibular areas in patients with a BMI of ≤ 46.2. It is also FDA-cleared to affect the appearance of lax tissue with submental area treatments.