100+ Peer-Reviewed Publications

Based on early experiments conducted by scientists Dieter Manstein, MD, PhD and R. Rox Anderson, MD, Cryolipolysis®, the concept behind CoolSculpting®, was invented.

Read about the CoolSculpting Cryolipolysis® procedure, the non-invasive fat reduction treatment with the most peer-reviewed publications.


Safety and Efficacy of Submental Cryolipolysis

Bernstein, E.F., Bloom, J.D. Safety and Efficacy of Submental Cryolipolysis. JAMA Facial Plastic Surg.

Long-term follow-up shows lasting results

Bernstein EF. Longitudinal Evaluation of Cryolipolysis® Efficacy. J Cosmet Dermatol.

No Impact On Serum Lipid Levels & Liver Function

Klein, K. B., Bachelor, E. P., Becker, E. V. and Bowes, L. E. Multiple same day Cryolipolysis® treatments for the reduction of subcutaneous fat are safe. Lasers in Surg.

Visible improvement & high patient satisfaction

Dierickx CC, Mazer JM, Sand M, et al. Safety, Tolerance, and Patient Satisfaction With Noninvasive Cryolipolysis®. Dermatol Surg.

Significant clinical practice business growth

Stevens WG, Pietrzak LK, Spring MA.Broad Overview of a Clinical and Commercial Experience With CoolSculpting. Aesthetic Surg J.

22% reduction in "love handles" fat layer

Dover J, Burns J, Coleman S, et al. A Prospective Clinical Study of Noninvasive Cryolipolysis® for Subcutaneous Fat Layer Reduction

No impact on lipid & liver function

Klein KB, Zelickson B, Ropelle JG, et al. Noninvasive Cryolipolysis® for Subcutaneous Fat Reduction Does Not Affect Serum Lipid Levels or Liver Function Tests. Lasers Surg Med.

No evidence of long-term nerve injury

Coleman SR, Sachdeva K, Egbert BM. Clinical Efficacy of Noninvasive Cryolipolysis® and Its Effects on Peripheral Nerves. Aesthetic Plast Surg.

Efficacy & safety demonstrated in studies

Avram MM, Harry RS. Cryolipolysis® for Subcutaneous Fat Layer Reduction. Lasers Surg Med.

Cryolipolysis® reduces excess adipose tissue

Nelson AA, Wasserman D, Avram MM. Cryolipolysis® for the Reduction of Excess Adipose Tissue. Semin Cutan Med Surg.

Decreases fat and changes body contour

Zelickson B, Egbert BM, Preciado J, et al. Cryolipolysis® for Noninvasive Fat Cell Destruction: Initial Results From a Pig Model. Dermatol Surg.

Proof of concept for Cryolipolysis®

Manstein D, Laubach H, Watanabe K, et al. Selective Cryolysis: A Novel Method of Noninvasive Fat Removal. Lasers Surg Med.

Real Patients,
Real Results

Real Patients Real Results

Fat-reduction outcomes can improve patient satisfaction. See "before & after" evidence.


Patient Demand

Undeniable Patient Demand

Offering the CoolSculpting procedure will delight your patients and benefit your practice.


35.3 MILLION people are interested in CoolSculpting specifically.* *Surveyed = US 18-75, HHI > $35K; N = 3547 (weighted); Quintessent Marketing analysis July 2017.